97th DOG Annual Meeting 1999
V615
CLINICAL DETECTION OF METASTASIS ASSOCIATED TUMOR
MICROVASCULARISATION IN UVEAL MELANOMA
F. Servetopoulou1, L. Krause1, J. Anagnostopoulos2, N. E. Bechrakis1
Purpose of this study is to identify clinically metastasis associated tumor specific vascular patterns in uveal melanomas using either fluorescein angiography or indocyanine green angiography and to correlate them with histopathological defined microvascularisation patterns (1).
Methods: 35 eyes with uveal melanomas were investigated using fluorescein angiography (n=34) and/or indocyanine green angiography with a scanning laser ophthalmoscope (n=15) prior to enucleation or local transscleral tumor resection. Vascular patterns thus visualized were compared to the histologically identified metastasis associated vascular patterns.
Results: Indocyanine green angiography and histology revealed the same tumor vascular pattern in 14 out of 15 cases, whereas fluorescein angiography in 18 out of 34 cases.
Conclusion: Histologically described metastasis associated tumor specific vascular patterns were detected in almost all cases with great accuracy using indocyanine green angiography with a scanning laser ophthalmoscope and in most of the cases using fluorescein angiography, allowing an evaluation of metastasis associated microvascularisation purely on clinical grounds.
(1) Folberg et al: Ophthalmology 100 (1993)1389-1398
1 Ophthalmology Dept., Klinikum Benjamin-Franklin, 12200 Berlin
2 Pathology Dept., Klinikum Benjamin-Franklin, 12200 Berlin
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