V 292
Antiphospholipid antibodies in patients with retinal vascular occlusion
R.-C. Lerche, G. Richard
Purpose: Lupus anticoagulants and antiphospholipid antibodies are antibodies against phospholipid-protein-structures and occur with hypofibrinolysis and thrombophilia.
Patients: A casereport of a 53-years old female with recurrent apoplexia and retinal vascular occlusion is presented to show seriousness of antiphospholipid-syndrome.
In a clinical trial blood samples of 78 patients with retinal vascular occlusion were taken and screened for anticardiolipin-anitbodies. In addition Lupus anticoagulants was measured in the last 25 patients with a high sensitive functional test.
Results: 11 of 78 (17%) patients showed increased anticardiolipin IgG-anitbodies. The prevalence for anticardiolipin IgM-antibodies was less (9%). A statistically correlation between increased anticardiodiolipin IgG-antibodies and retinal venous occlusion was found. The Lupus anticoagulants was positive in only patient.
Conclusion: Increased antiphospholipid antibodies seems to play an important role for thrombophilia and pathogenesis of retinal vascular occlusion. Anticardiodiolipin IgG-antibodies were significant higher for venous than for arterial retinal occlusion. In case of vascular occlusive disease the Lupus anticoagulants / antiphospholipid anitbody-screening is recommended.
University eyeclinic, Martinistrasse 52, D-20246 Hamburg