V 355
Comparison of frequency doubling perimetry vs standard automated perimetry in glaucoma and age-related maculopathy
J. Kampmeier, B. Eisert, G. K. Lang, G. E. Lang
Purpose: To compare Frequency Doubling Perimetry (FDP) versus standard automated perimetry in glaucoma, involving primarily My ganglion cells, and age-related maculopathy (ARM), involving photoreceptor cells. To evaluate the reproducibility of both methods.
Methods: All the patients were tested twice with both FDP and Humphrey Field Analyzer II Model 750 (HFA) in random sequence, within one day. The parameters mean deviation (MD), pattern standard deviation (PSD) and measured thresholds per quadrant and center areas were evaluated for FDP/HFA comparison in 45 glaucoma- and 35 ARM-patients. The same parameters were used for testing the reproducibility of FDP and HFA. Additionally, the center and each quadrant area were checked for any deviation in the total deviation probability plots.
Results: In glaucoma patients an average MD (FDP vs HFA) of -7.3 ± 5.8 dB vs -8.9 ± 7.6 dB and PSD of 6.9 ± 2.4 dB vs 6.5 ± 3.6 dB were found. Kappa coefficients denote marginal accordance (kappa: 0.11-0.38) for area deviations. In a total of 225 areas HFA detected 191 deviations and FDP 165. HFA measured more negative deviation in the case of MD < -15 dB. The reproducibility was 0.98 (MD) and 0.92 (PSD) for FDP and 0.98 (MD) and 0.95 (PSD) for HFA. In ARM patients an average MD (FDP vs HFA) of -1.1 ± 4.5 dB vs -7.0 ± 6.3 dB and PSD of 6.4 ± 3.0 dB vs 5.1 ± 2.9 dB were found. Kappa coefficients denote no accordance (kappa: 0.03-0.08) for area deviations, except for the upper nasal quadrant (kappa: 0.14). In a total of 175 areas HFA detected 146 deviations and FDP 54. HFA measured a more negative deviation in the case of MD < -5 dB. The reproducibility was 0.72 (MD) and 0.67 (PSD) for FDP and 0.72 (MD) and 0.61 (PSD) for HFA.
Conclusions: There was greater conformity between FDP and HFA in glaucoma- than in ARM-patients. HFA detected more deviations in the total deviation probability plots than FDP. The reproducibility of both methods was lower in ARM patients. FDP is an appropriate tool for detecting visual field loss in retinal diseases involving the magnocellular system, such as glaucoma. However, FDP is less useful than HFA for the examination of ARM-patients.
Dept. of Ophthalmology, University of Ulm, Prittwitzstr. 43, D-89075 Ulm