Results: The age of the patients was 46 to 70 years, relation of gender was 3 : 3. In all patients, ocular involvement preceeded CNS symptoms (latency up to 17 months). In three patients, the primary ocular involvement was diagnosed as inter-mediate uveitis, in two patients as panuveitis, and in one patient as choroidal metastasis. Systemic corticosteroids led to moderate reduction of inflammation in two of these misdiagnosed cases of uveitis, but finally induced late definite diagnosis. Diagnostic vitrectomy (n = 4) has shown atypical cells in one patient but an Interleukin (IL) 10 to Interleukin 6 relation > 1 was demonstrated in two additional patients. The definite diagnosis was possible in one patient by histology of the enucleated eye, in two additional patients after stereotactic biopsy from brain tissue. All patients had developed a highly malignant NHL of B-cells. For the first period, the best therapeutical results were achieved by the combination of radiation and cytostatic therapy, but two patients died in the following treatment period.