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Impressum
Laser Therapy of Intraocular Neoplasms
Augsburger J. J.
University of Cincinnati, Cincinnati, Ohio, USA
Purpose: To evaluate the role of laser therapy in treatment of
selected intraocular neoplasms.
Methods: Retrospective analysis of published case series and personal
experience.
Results: There are no published clinical trials of laser therapy
versus other management methods for intraocular neoplasms. All available
information about effectiveness of laser therapies comes from uncontrolled,
nonrandomized clinical studies. Laser therapy alone is clearly able to
obliterate some small intraocular neoplasms. However, it is frequently
associated with local tumor relapse that then requires more aggressive
therapy. Laser therapy combined with plaque radiotherapy increases the
rate and completeness of regression of choroidal melanomas and appears
to reduce the rate of local relapse. Similarly, laser therapy as a supplement
to chemotherapy increases local treatment success in retinoblastoma. Photodynamic
therapy has been used with considerable success in treatment of small
circumscribed choroidal hemangiomas.
Conclusions: Laser therapy appears to have a limited role in treatment
of intraocular neoplasms.