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Impressum
Long term follow-up of HLA-A and -B matched high-risk corneal transplantations
Beekhuis W. H.
Cornea service, The Eye Hospital, Rotterdam; Eurotransplant, Leiden; Immunohaematology Dpt., Leiden
Objective: Evaluation of long term results of high-risk transplantations
and investigating the influence of HLA-A and -B matching on graft survival.
Methods: Retrospectively we analysed the follow-up results of 312
highrisk patients, who underwent a HLA-A and -B matched graft between
1982 and 1995 in The Rotterdam Eye Hospital. Transplant functionality
and allograft rejections were documented throughout the follow-up. Kaplan-Meier
method was used to determine the rejection-free transplant survival for
patients with 3 and 4 HLA-A and-B matches and compared with those patients
who received a donor cornea with only 2 matches.
Results: Total 5-year survival in these high risk cases was 59,3
%. When the data were analysed on split-matches, the group with the better
matching performed significantly better, especially during the first 3
years after transplantation.