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Impressum
Photodynamic Therapy (PDT) as treatment of Age-Related Macular Degeneration with predominantly classic choroidal neovascularisation(CNV)
Behme T., Wachtlin J., Potthöffer S., Foerster M. H.
Augenklinik, Univ. Klinikum Benjamin Franklin, FU Berlin, Hindenburgdamm 30, 12200 Berlin
Background: In Europe and the United States PDT is the therapy
of choice for AMD with predominantly classic subfoveal CNV. The results
of the TAP-study with a three-year-follw-up period have shown a stabilization
of visual acuity (VA) in most patients. It has to be shown wether these
results can be reached in clinical routine.
Methods: Since October 1999 145 patients with predominantly classic
subfoveal CNV in AMD were treated with PDT (Verteporfin) in a prospective
study. The Follow-up period was at least 3 months in 100 patients which
are included in this evaluation. The average age was 73,1 years (51-91)
and the mean follow-up-time was 7,8 month (sd = 3,9 ). The mean diameter
of the lesions was 2490 mm; on average 2,4 sessions of treatments were
performed (1 - 5).
Results: The mean visual acuity devellopment was - 1,5 lines on
the EDTRS-chart (-10 to + 8). 18 patientents (18 %) have shown an increase
of the VA = 2 lines, in 44 cases (44 %) was the VA constant (+/- 1 line)
and 38 patients (38%) had a deteriation of vision = 2 lines.
Conclusion: In most cases a predominantly classic CNV secondary
to AMD can be treated successfully with PDT. The results of the TAP-study
can be reached under clinical routine conditions