1,2Bialasiewicz A. A., 1Kondek T.

1Universitäts-Augenklinik Eppendorf, Hamburg; 2Department of Ophthalmology, SQUH University of Oman, Al Khod/Muscat

Objective: To evaluate clinical data and incidence of bone formation and monocytic cell infiltrates in secondary osseous metaplasia.
Methods: 216 of 3850 globes (=5.32%) examined from 1968-1997 by routine histology exhibited bone formation. Data of the patients were collected, and specimens were stained for CD68, a lysosomal glycoprotein mainly found in the cytoplasm of monocytes, by a three-step avidin-biotin technique (LSAB-2kit, DAKO, Hamburg).
Results: Primary clinical events had been trauma (120), uveitis (35), retinal detachment (30), glaucoma (12) and miscellaneous others. Final histopathological diagnoses were retinal detachment (167) (and PVR (143)), glaucoma (111), cataract (103), cyclitic and retrocorneal membranes (83), and choroidal detachment (49). Localization of bone formation was intraretinal (62), subretinal (62), RPE (47), choroid (30), and papilla (19). Time elapsed between the initial ocular disease and enucletion was 2-73 years (mean 24.9 years). All of the specimens showed periosseous chronic inflammatory infiltrates, and 80/216 (37.1%) stained strongly and densely (0-10/hpf: 14=175%, 11-50/hpf: 54=67.5%, 51-80/hpf: 12=15%) positive for CD68.
Conclusions: In this histopathology material, the most important pathogenesis for intraocular osseous metaplasia is trauma followed by retinal detachment, and PVR and chronic inflammation involving the recruitment of CD68+ monocytes.

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