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Impressum
Functional and morphological changes after chronic treatment with chloroquine in the retina of mice
Bredehorn T., Duncker G.
Department of Ophthalmology of the Martin-Luther-Universität Halle- Wittenberg, Magdeburger Str. 8 ,06097 Halle/Saale, Germany
Objective: A series of dicationic amphiphilic drugs are known
to induce generalized lipidosis. The present study deals with the cytological
effects of the antimalariadrug chloroquine upon the retina of mice.
Methods: The animals were treated orally with chloroquine for a
periods up to 16 weeks at a dose range of 60-90 mg/kg of body weight,
and the retinae were examined by light and electron microcopy. Erg-measurements
were done initially and after 16 weeks of treatment.
Results: All types of retinal cells developed abnormal cytoplasmic
vacuoles which represented the ultrastructural counterpart of lysosomal
storage. The retinal pigment epithelium and the ganglian cells were most
prominently affected. After treatment of 16 weeks, the a-and b-wave in
Erg was reduced compared with the controls.
Conclusions: The present results suggest that the retinal pigment
epithelium and ganglian cells must be engaged in lysosomal storage of
chloroquine. We suppose that the severe storage of lipid-drug complexes
caused secondary cellular disturbance responsible for the functional changes
shown by electroretinography.