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Impressum
The ratio of transplanted to all donated corneas after long-term cultivation: Is there an Influence of post mortem time, donor age and endothelial cell density before preservation?
1Carstens J., 1Scholz F., 1Richard G., 2Böhnke M., 1Engelmann K.
1University Eye Hospital Hamburg-Eppendorf, Martinistr. 52 20246 Hamburg, 2Eyehospital Rothenbaumchaussee, 20149 Hamburg
Purpose:The aim of this study was to elucidate influencing factors
on ratio of transplanted to all donated corneas.
Methods: The data of this study were derived from an Access database
depending on documentation of donor tissue during the period from 1981
to 1999 in the Hamburg Cornea Bank. Data was analyzed for donor age, endothelial
cell density before tissue preservation, post mortem time and utilization
of donor tissue (transplanted or not). Incomplete data was discarded.
In order to calculate the ratio, three age groups were created (11-49y,
50-69y, 70-100y). Endothelial cell density was divided into three groups
(less than 2000, 2000-2500 and more than 2500 cells/mm²). Postmortem
time from 0 to 100 hours was divided into 5 groups (20 hours per group).
Ratio was calculated depending on age group and endothelial cell density
as well as age group and post mortem time.
Results: Between 1981and 1999, 7116 corneas were donated. The data
of 5607 donor corneas were complete and hence could be evaluated. Mean
endothelial cell density decreased from 2849 cells/mm² in age group
I (11- 49y n=1800) over 2606 cells/mm² in group II (50-70y, n=2412)
to 2356 cells/mm² in group III (70-100y, n=1395). Within age group
I endothelial cell densities over 2500 cells/mm² had the highest
ratio (61,76%) and cell densities 2000-2500 cells/mm² showed ratio
of 45,89%. However within age group III ratio was nearly independent from
cell density. With rising postmortem time a steady decrease of ratio was
observed in age group I (61,03% up to 20 hours post mortem (hpm) to 42,86%
up to 80 hpm) whereas the older donors showed stable ratio around 30%
in all hpm groups.
Conclusions: Post mortem time and endothelial cell density have
a significant influence on the ratio in younger donors. Ratio in old donors
was more stable and nearly independent from these factors. However the
overall ratio in old donors was still about 30%.