Anmeldung zur Tagung
Registration
Grußwort
Invitation
Themen
Topics
Allgemeiner Ablauf
General overview
Wissenschaftliches Programm
Scientific program
Kurse
Courses
Symposien
Symposiums
Frühstück mit Spezialisten
Breakfast with specialists
Arzthelferinnen-Fortbildung
Rahmenprogramm
Social program
DOG Information
DOG Information
Allgemeine Informationen
General Information
Autorenindex
Index of Authors
Ausstellerliste
Exhibitors
Sponsoren
Sponsors
Teilnahmegebühren
Registration fees
Impressum
Advanced Glycation End-Products (AGEs) and Cataract - Distribution in different types of cataract
1Dawczynski J., 2Franke S., 1Blum M., 3Kasper M., 2Stein G., 1Strobel J.
1Dept. of Ophthalmology, 2Dept. of Internal Medicine IV, Friedrich-Schiller University Jena, Germany; 3Institute of Anatomy, Technical University of Dresden, Germany
Objective: AGEs could be found in different systemic and ocular
diseases. This study aimed to investigate the expression and distribution
of the AGEstructure carboxymethyllysine (CML) in human lenses with different
types of cataract.
Methods: Parraffin sections of 48 human cataractous lenses were
immunohistochemicaly investigated using a polyclonal (CML) antibody.
Results: In nearly all lenses a positive immunoreactivity for CML
could be found. Nethertheless, there were clear differences concerning
the distribution of CML in different types of cataract. Diabetic lenses
showed the strongest immunoreactivity of all examined lenses.
Conclusion: This investigations provide evidence for a possible
influence of AGEs in the pathogenesis of cataract. Especially in mature
cataractous lenses and diabetic lenses a strong accumulation of AGEs could
be shown. Further investigations should show if these findings are a cause
or the result of the complex process of lens opacification.