Deuter C. M. E., Stübiger N., Bräuning J., Derse M., Zierhut M.

University Eye Hospital, Department I, Schleichstr. 12, D-72076 Tübingen

Objective: A familial accumulation in some forms of uveitis has rarely been described. The objective of this study was to identify such cases and to examine both clinical progress and similarities in the HLA-pattern.
Methods: From 1993 to date all new uveitis patients, which were examined in our special clinic, were questioned about an uveitis disease in their family. All affected family members underwent an ophthalmological examination; an HLA-typing was done.
Results: In altogether 7 families we found a familial accumulation of uveitis. Causes were: Anterior uveitis in Blau Syndrome (uveitis with arthritis and dermatitis) without HLA-association (1 family with a total of 11 affected individuals; autosomal dominant mode of inheritance; significant anticipation). Anterior uveitis in Morbus Bechterew with HLA B27- association (3 families with a total of 10 affected individuals). Anterior and intermediate uveitis in sarcoidosis without HLA-association (1 family each, 6 affected individuals altogether) and panuveitis in Morbus Behçet with HLA B51-association (1 family with a total of 2 affected individuals).
Conclusion: Our study confirms that familial forms of uveitis are very rare. We suggest that these may be subgroups of known uveitis syndromes (e.g. sarcoidosis, Morbus Bechterew). The factors causing the inheritance are still unknown. By examination of families with uveitis it may be possible to identify uveitis genes or possible antigens.

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