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Impressum
Three-dimensional topographic angiography (TAG) and Optical Coherence Tomography (OCT): a comparison
1Elsner H., 1Niemeyer M., 2Birngruber R., 1Laqua H., 1Schmidt-Erfurth U.
1University Eye Hospital Lübeck, 2Medical Laser Center Lübeck
Objective: To compare three-dimensional topographic angiography
(TAG) and optical coherence tomography (OCT) and to characterize their
specific capabilities in imaging choroidal neovascularization.
Methods: 30 patients presenting with choroidal neovascularization
have been examined by two imaging modalities. Topographic angiography
(TAG) was performed, capturing 32 tomographic series of horiziontal cross-sections
during a confocal fluorescein- and indocyanin-green angiography and applying
a newly developed software for threedimensional data analysis. Optical
Coherence Tomography (OCT) was carried out with a slitlamp-adapted system
under ophthalmoscopic control.
Results: Both imaging techniques, TAG and OCT are reliable in detecting
the chorioretinal lesion. Localisation and hight of the neovascular complex
are identical in both modalities. However, significant differences became
apparent in terms of delineation of vascular and extravascular structures.
In TAG an isolated documentation of the physiologic surface of the choriocapillaris
and neovascular components was possible. Blockage phenomena caused by
blood, serous fluid and overlying layers of RPE had no impact on visibility.
Localisation of CNV is precise and easily delineated from individually
configured extravascular structures. OCT allows no differentiation between
(neo-)vascular or avascular tissues. CNV shows up as an unspecific part
of a thickening or elevation of the highly reflective layer of RPE and
anterior choriocapillaris. CNV-associated phenomena like intra- and subretinal
fluid are only detectable by OCT.
Conclusion: The comparison of TAG with an established imaging technique
like OCT shows TAG being a realistic method to visualize CNV. The isolated
view of CNV is a clear advantage of TAG, while OCT is the better choice
to assess CNV-associated intra- and subretinal structural changes.