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Impressum
Impact of anticoagulant drugs on the size of subretinal haemorrhage in age-related macular degeneration
Fischer I. B., Hattenbach L. O., Koch F., Ohrloff C.
Klinik für Augenheilkunde, Klinikum der Johann Wolfgang Goethe- Universität, Frankfurt am Main
Purpose: Subretinal haemorrhage is a common complication in patients
with age-related macular degeneration (ARMD). Due to their generally advanced
age, they frequently suffer from additional systemic illnesses. These
often make an anticoagulant therapy necessary. In the current study, we
investigated whether there is a correlation between anticoagulant therapy
and the size of subretinal haemorrhages.
Methods: Eighty consecutive patients with subretinal haemorrhages
secondary to exsudative ARMD were included in this study. Depending on
the size of haemorrhage, patients were divided into two groups (>/=
4.5 or <4.5 DA = three times the median of subretinal haemorrhage).
Fisher's exact test was used for group comparison.
Results: Of 22 patients with subretinal haemorrhage >/= 4.5
DA, 11 were either on warfarin or salicylic acid ( P = 0.01). Subgroup
analysis revealed a statistically significant difference with respect
to treatment with warfarin: 5 out of 22 patients (23%) developed haemorrhages
>/= 4.5 DA, 3 out of 58 (5%) haemorrhages < 4.5 DA in size ( P=
0.033).
Discussion: Anticoagulant therapy has an impact on the size of
subretinal haemorrhages in patients with exudative ARMD. The funduscopic
status should be taken into account when prescribing anticoagulant drugs.