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Impressum
Multifocal ERG: Age-related changes for different luminance levels
Gerth C., Garcia S., Mas M., Keltner J., Werner J. S.
University of California Davis, Department of Ophthalmology, 4860 Y Street, Suite 2400, Sacramento, CA 95817, USA
Objective: To investigate age-related changes in the first-order
multifocal electroretinogram (mfERG) responses of normal subjects for
different luminance levels.
Methods: Normal subjects from age 10 to 80 years (best-corrected
VA: = 20/25, refractive error + 4.0 dpt to- 6.0 dpt, no ocular abnormalities
other than age-related changes in lens density) were included in the study.
The mfERG responses were recorded with the 7" stimulus-refractor
unit (EDI) and VERIS 4.3. with the following protocol: bipolar contact
lens, 103 hexagons, consecutive stimulation with 200 and 700 cd/m2 , pupils
>/= 6mm, amplification 105, filter cut-offs at 10 and 300 Hz.
Results: So far we have collected and analyzed data from 50 (29
female, 21 male) subjects. The mean overall response densities for both
luminance levels and the luminance response difference declines with age
(mean difference 10-19 years: 12.9 nV/deg2; 70-80 years: 8.99 nV/deg2).
The rate of decline with age was more rapid for 700 cd/m2 compared to
200 cd/m2 (p < 0.001). The response densities were higher in the temporal
(T) than in the nasal (N) retina [mean T-N: 3.36 nV/deg2 (200 cd/m2),
p=0.036; 3.18 nV/deg2 (700 cd/m2), p=0.07] without age-related differences.
There was no statistically significant difference in the response densities
from the inferior (I) and superior (S) retina [mean I-S: 0.98 nV/deg2
(200 cd/m2), p=0.37; 1.22 nV/deg2 (700 cd/m2), p=0.48]. For both luminance
levels, the overall peak time P1 differed for all age groups, (10-19 >
20-29 >30-39 < 40-49 < to 80 years). A gender effect was found
for the overall peak times but not for the response densities [mean P1
(200 cd/m2): 28.30 ms (F), 29.08 ms (M), p=0.05; (700 cd/m2): 27.61 ms
(F), 28.45 ms (M), p=0.037].
Conclusion: Different luminance levels showed a different age effect
on the first order mfERG response densities with a sensitivity loss in
older age. An age- and gender-related peak time change could be identified.