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Impressum
Anisometropia and Degree of Glaucomatous Optic Neuropathy in Chronic Non-Highly Myopic Open-Angle Glaucoma
1Harder B., 1,2Jonas J. B.
1Department of Ophthalmology and Eye Hospital, Faculty of Clinical Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany; 2Department of Ophthalmology and Eye Hospital, University Erlangen- Nürnberg, Erlangen
Objective: Myopie has been discussed as risk factor for the devlopment
and progression of glaucomatous optic neuropathy in the chronic openangle
glaucomas. To address the question whether the refrective error plays
a role in the amount of optic nerve damage in glaucoma, the purpose of
the present study was to compare inter-eye differences in refractive error
with inter-eye differences in parameters indicating the degree of glaucomatous
optic nerve damage.
Patients and Methods: The comparative clinical observational study
included 1086 patients with primary or secondary open-angle glaucoma.
Patients with a highly myopic refractive error exceeding -8 diopetrs were
excluded due to differences n the anatomy of the optic nerve head. For
all patients color stereo optic disc photographs had been taken and were
morphometrically evaluated. Main outcome measures were optic disc size,
neuroretinal rim area, horizontal and vertical cup/disc diameter ratios
corrected for optic disc size, and visual field loss.
Results: In an interindividual statistical analysis, area of neuroretinal
rim, horizontal and vertical cup/disc diameter ratios, and mean visual
field loss were not significantly correlated with the refractive error.
In an intraindividual inter-eye comparison, the eye with the more myopic
refractive error and the contralateral eye with the less myopic refractive
error did not vary significantly (P>0.10) in neuroretinal rim area,
cup/disc ratios, and visual field defect.
Conclusions: For non-highly myopic patients with chronic open-angle
glaucoma, myopic versus hyperopic refractive error may not play an important
role for the amount of glaucomatous optic neuropathy.