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Impressum
Influence of optic disc area on scanning laser polarimetry in healthy subjects
Hayler J. K., Horn F., Nguyen N. X ., Mardin C. Y.
Dept. Ophthalmology Univ. Erlangen-Nürnberg, Schwabachanlage 6, D- 91054 Erlangen
Background: To investigate the influence of optic disc area on
the measurements of scanning laser polarimetry (GDx, Co. Laser Diagnostics
Technologies, San Diego) in healthy eyes.
Patients and Methods: We investigated 56 normal eyes (31 male/
25 female) of patients of the Erlanger glaucoma register with disc area
ranging between 1,6 and 4,8 mm2 (assessed by planimetric measurements)
by GDx. Following variables of the GDx were correlated (Pearson) with
the disc area: the number, superior/temporal ratio, superior/nasal ratio,
inferior/ temporal ratio;average thickness
Results: The average thickness of the retinal nerve fibre layer
did not correlate (r=0,08; no significance) with disc area. With increasing
disc area the number increased significantly (r= 0,55; p<0,0001). The
ratios of the retinal nerve fibre layer thickness (RNFLT) of following
quadrants did show significant decrease with increasing disc area: superior/temporal
ratio (r=-0,27; p=0,004), superior/nasal ratio (r=-0,48; p<0,0001),
inferior/temporal ratio (r=-0,25; p=0,007).
Discussion: The measurements of the GDx are influenced by the optic
disc area. Anatomical factors like the different quantity of the retinal
nerve fibres and there arrangement within the area measured in large versus
small discs might play a role. Using GDx as a diagnostic tool for glaucoma,
disc area should be encountered to avoid possible systematic errors and
to increase the diagnostic value of the device.