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Impressum
Differences in the 24 hour blood pressure measurement of healthy volunteers and patients with glaucoma
Hendricks S., Plange N., Huber K., Remky A., Arend O.
Augenklinik der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
Purpose: Both arterial hypotension and hypertension are known
risk factors for progression in glaucoma. In this evaluation the blood
pressures of healthy volunteers and patients with glaucoma were determined
by 24 hour ambulatory blood pressure measurement (ABPM).
Methods: We examinated 23 patients with POAG and NTG (9 m, 14 f,
mean age 62 ±10 years) and 10 healthy voluteers (6 m, 4 f, mean
age 56 ±11 years). The systolic, diastolic and mean arterial blood
pressures were taken every 30 minutes by ABPM (SpaceLabs Medical, Inc.)
during the day (8 am to 8 pm) and at night (0 am to 6 am). In addition,
the standard deviations (SD) and coefficients of variation (CV) were calculated
as parameters of the fluctuation of blood pressure. A patient with a depression
in blood pressure about 10% is classified as "dipper".
Results: Glaucoma patients and healthy volunteers showed no differences
in age, intraocular pressure and pressure decrease at night. Over the
day there is neither significant difference between the groups for the
systolic, diastolic and mean arterial blood pressure; nor for SD and CV.
During the night there is no significant difference between healthy volunteers
and patients with glaucoma in systolic, diastolic and mean arterial pressure.
However, glaucoma patients showed a significant increase in SD and CV
of diastolic (SD p=0,01; CV p=0,026) and mean arterial pressure (SD p=0,009;
CV p=0,02) at night.
Discussion: Patients with glaucomatous optic neuropathy showed
increased SD and CV of the diastolic and mean arterial pressure at night.
Increased values can be regarded as a dimension for the inhomogenity of
blood pressure. Fluctuations of the diastolic and mean arterial blood
pressure by night are possibly a cause of neurodegeneration or progression
of glaucomatous damage