Anmeldung zur Tagung
Registration
Grußwort
Invitation
Themen
Topics
Allgemeiner Ablauf
General overview
Wissenschaftliches Programm
Scientific program
Kurse
Courses
Symposien
Symposiums
Frühstück mit Spezialisten
Breakfast with specialists
Arzthelferinnen-Fortbildung
Rahmenprogramm
Social program
DOG Information
DOG Information
Allgemeine Informationen
General Information
Autorenindex
Index of Authors
Ausstellerliste
Exhibitors
Sponsoren
Sponsors
Teilnahmegebühren
Registration fees
Impressum
Etiologies for diffuse lamellar keratitis: Animal study
Holzer M. P., Solomon K. D., Vargas L. G., Vroman D. T., Apple D. J.
Storm Eye Institute, Medical University of South Carolina, 167 Ashley Ave, Charleston SC, 29425, USA
Objective: Diffuse Lamellar Keratitis (DLK) is a common complication
following LASIK surgery. Aim of this study was to evaluate the etiologic
factors for DLK.
Methods: In 70 eyes of Dutch Belted rabbits a corneal flap was
cut and the interface inoculated with 7 different substances (Pseudomonas
aeruginosa endotoxin, Staphylococcus aureus exotoxins, Meibomian gland
secretion, Povidine-Iodine, Palmolive and Klenzyme cleaning soap). 8 eyes
without any inoculation were in the control group. Slit lamp examinations
were performed 1, 3, 5 and 7 days postoperatively. On day 7 the eyes were
enucleated for histopathological examination.
Results: During the postoperative follow-up period DLK was found
in 2/3 of the eyes. All the tested agents caused DLK. The highest DLK
rate was found for the soaps and the Pseudomonas endotoxin. All of the
control eyes remained clear.
Conclusion: DLK after LASIK is a multifactorial disease, which
can be caused by different agents. Pre- and perioperative hygiene regimens
are very important to minimize DLK rates.