Horn F. K., Dehne K., Jünemann A. M., Korth M.

Univ.-Augenklinik, D-91054 Erlangen, Schwabachanlage 6

Introduction: Aim of this study was to evaluate the diagnostic usefulness of the FDT screening procedure in combination with a newly developed database system.
Subjects: 54 ocular hypertensive eyes, 54 "preperimetric" open angle glaucoma eyes (glaucomatous optic disc atrophy, elevated introcular pressure, no visual field defects), 72 "perimetric" open angle glaucoma eyes (glaucomatous optic disc atrophy and visual field defects), 61 control eyes.
Methods: FDT screening, conventional white/white perimetry and papillometry in all subjects. The present screening strategy (procedure: C- 20-5) starts testing at the normal 5% probability level. If a stimulus is not detected further targets are presented. This study uses data transfer (FDTViewfinder, Humphrey) and statistics software (SPSS 10) for casewise recalculation of all missed localized probability levels. Two or more missed adjacent locations can be automatically detected and considered in the classification. In addition, single missed locations can be judged due to random variation.
Results: The number of abnormal test locations as well as the test duration of the whole procedure are sensitive parameters in differentiating eyes with glaucoma from normal and ocular hypertensive eyes. At a predefined specificity of 90% in control eyes 14% of ocular hypertensive eyes, 41% of "preperimetric" glaucoma eyes and 84% of "perimetric" have been classified glaucomatous.
Discussion: Data base analysis is necessary for classification of patient groups, automatic detection of adjacent missed probability levels, and for consideration of the individual learning curve in repeated measurements. Supported by: DFG (SFB 539)

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