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Impressum
Atopic keratoconjunctivitis: Cause for conjunctival carcinoma?
1Kallen C. J., 1Reinhard T., 1Cartsburg O., 2Böcking A., 1Sundmacher R.
1Eye Hospital and 2Institute of Cytopathology, Heinrich-Heine University, Düsseldorf
Objective: In Germany, the incidence of conjunctival carcinoma
approximates 1.2/1 million/year. In 2000, 5 patients with atopic keratoconjunctivitis
developed conjunctival carcinoma in the Heinrich-Heine University. Since
October 2000 all patients with atopic keratoconjunctivitis, therefore,
have been monitored via cytology and cytometry.
Patients and methods: Sixteen patients have been examined so far.
The age of 9 male and 7 female patients averaged 45.8+/-12.7 years. The
patients had suffered from atopic disease for 31.6+/-16.7 years. The eyes
had been involved for 8.2+/-8.5 years.
Results: Conjunctival carcinoma was diagnosed in 2/16 patients.
In one patient the disease was invasive, in the other it was graded as
carcinoma in situ.
Conclusion: The detection of 2 conjunctival carcinomas in 16 patients
supports the suspicion of an elevated incidence of the disease in atopic
keratoconjunctivitis. A larger group of patients has to be followed in
order to concretize this suspicion.