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Impressum
Ocular blood flow and retrobulbar perfusion in normal pressure and primary open angle glaucoma
Köller A. U., Pillunat L. E., Müller M. F., Bernd A. S., Böhm A. G., Mollenhauer K. A.
University Eye Hospital Dresden
Purpose: Vascular factors are of pathogenic importance in developing
glaucomatous optic nerve atrophy. Especially in normal pressure glaucoma
a reduced blood flow of the optic nerve head seems to play a major role.
The aim of the present study was to investigate ocular blood flow and
retrobulbar perfusion in untreated patients with normal pressure- (NPG)
and primary open angle glaucoma (POAG).
Material and methods: 18 patients (7 male, 11 female; mean age
61 years ) with untreated NPG and 15 (7 male, 8 female; mean age 56 years)
with untreated POAG were included in the study. Retinal capillary blood
flow was measured by Scanning Laser Doppler Flowmetry (HRF) and for the
measurement of capillary optic nerve head blood flow Laser Doppler Flowmetry
(LDF) was used. Choroidal hemodynamics and ocular pulse amplitudes were
examined by means of the OBF-System. The flow velocities of the ophthalmic
artery, the central retinal artery and the short posterior ciliary arteries
were measured by colour Doppler Imaging (Siemens Sonoline Elegra). For
statistical analysis the Mann-Whitney-U Test was used.
Results: There was found no significant difference between NPG-
and POAG patients with regard to age, blood pressure and heart rate. The
IOP was significantly lower in the NPG group (NPG :13,8 +/- 2,4 mmHg;
POAG :17,5+/-3,1 mmHg). All measured parameters of ocular blood flow and
retrobulbar hemodynamics did not show any significant differences between
the two groups examined.
Conclusion: Ocular and retrobulbar hemodynamics did not show any
significant differences between untreated NPG- and POAG patients. Therefore
also other pathogenic factors like a reduced individual pressure tolerance
of the optic nerve head have to be taken into account.