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Impressum
Does a single drop of topical neosynephrine 10% influence retinal branch vein diameter?
1Lanzl I. M., 2Vilser W., 1Kotliar K. E.
1Eye Clinic, Munich University of Technology, Ismaninger Str. 22, Munich, 2Ilmenau University of Technology, G.-Kirchhoff-Str.1, Ilmenau, Germany
Background: Topical neosynephrine 10% is widely used as a mydriatic
agent in ophthalmology. It also acts as a potent vasoconstrictor as can
be seen by vessel blanching of the conjunctiva. The aim of this study
was to determine, whether a single drop of topical neosynephrine 10% is
able to influence retinal branch vein diameter.
Methods: The diameter of retinal branch veins after neosynephrine
10% application was assessed in 30 young healthy volunteers by means of
Retinal Vessel Analyzer (RVA). The changes in vessel diameter were observed
for 28 minutes after application. Every 2 minutes pulse and systemic blood
pressure were assessed as well.
Results: A raise of mean systemic blood pressure of about 5 mmHg
could be observed within 6 minutes of eye drop application. Blood pressure
later returned to baseline values. Compared to baseline 36% of the volunteers
showed a mean dilation of branch vessel diameter of 8.5 ± 3.4 %,
36% showed a mean constriction of branch vessel diameter of 8.2 ±
5.2 % and in 28% of volunteers no change of diameter could be observed.
Discussion: A small, however significant raise in mean systemic
blood pressure could be observed after neosynephrine 10% application.
Depending on the need for local retinal autoregulation to counteract this
effect and basic adrenergic tonus of the volunteers different regulating
effects of branch veins could be observed in our study. We recommend not
to use neosynephrine 10% eye drops to induce mydriasis for examinations
of retinal blood flow in order to rule out possible confounding factors
caused by neosynephrine application.