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Impressum
Relationship between age and optic nerve head stereometric parameters in normal subjects
Markowska J., Romaniuk W., Koziol H., Lelek M., Klimek J.
Department of Ophthalmology, Silesian School of Medicine, St. Barbara Specialist Hospital, Sosnowiec, Poland
Purpose: To assess the topographic differences between baseline
and follow-up examination and correlation between age and Optic nerve
head stereometric parameters in normal subjects using Heidelberg Retina
Tomograph.
Material: 48 individuals (96 eyes): 33 women (66 eyes), 15 men (30 eyes),
age 40-70 yrs (mean: 51,90 yrs), no ocular disease, no family history
of glaucoma, the best correted visual acuity VA = 0,5 and refractive error
= ± 4Dsph, 1Dcyl, intraocular pressure measured with Goldmann applanation
IOP < 21 mmHg in both eyes, normal anterior segment of eye in slit
biomicroscopy, normal open angle in genioscopy, normal funduscopy, normal
reliable static achromatic perimetry and classification HRT = Normal.
Method: Change of optic nerve head (ONH) stereomelric parameters
during time of two years and correlation with age were estimated. To investigate
the stereometric parameters of ONH we used confocal scanning laser ophthalmoscop
- Heidelberg Retina Tomograph (Heidelberg Engineering GmbH, Heidelberg,
Germany, version 2.01). Following topographic ONHparameters in healthly
volunteers were analized: disc area (DA), cup area (CA), cup/disc area
ratio (C/D), rim area (RA), height variation contour (HVC), cup volume
(CV), rim volume (RV), mean cup depth (MCD), maximum cup depth (MxCD),
cup shape measure (CSM), mean retinal nerve fiber layer thickness (M RNFLTh),
RNFL cross-section area (RNFL csa). For evaluation changes of ONH stereometric
parameters between baseline and follow-up examination t-Student test was
used. The effect of age on each parameter was statistically analyzed by
linear regression and correlation model (y=ax+b). The level of statistical
significance used was p < 0,05.
Results: No significant change in ONH stereometric parameters was
observed during follow-up. This study showed that two of the optic nerve
head parameters obtained with the HRT correleted with age. These are:
CSM (p=0,0144), MRNFLTh (p=0,0178). The results are shown in Table 1 and
2.
Conclusions: There are statistically significant correlations between
CSM, MRNFLTh and age which can make these parameters inadequate for monitoring
of other then age related atrophic ONH changes. Care should be taken to
evaluate. the topography of the ONH on the basis of