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Impressum
Endothelin-1 and Ophthalmic Artery Elasticity during cold stimulation in Low Tension Glaucoma
Michelson G., Harazny J., Dannescheid M.
Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg, 91054 Erlangen
Background: Low Tension Glaucoma is probably no homogenous group
of diseases. These patients show often "vasospastic symptoms",
"arteriosclerotic alterations" or "arterial hypotension".
The purpose was a discrimination of the group of Low Tension Glaucoma
by Endothelin-1 plasma concentration and ophthalmic artery elasticity
during cold stimulation.
Method: 20 patients with Low Tension Glaucoma and 14 controls were
examined in respect to Endothelin-1 plasma concentration and ophthalmic
artery elasticity before and during cold stimulation. In all subjects
Endothelin-1 was determined after a 30 min rest and after a 5 min cold
stimulation (hand in water of 4°C). The pulse curves of the ophthalmic
artery, the arterial blood pressure, the heart rate, and finger nail blood
flow was continuously measured 5 min before, 5 min during, and 5 min after
cold stimulation. The pulse curves were analysed by Fast Fourier Transformation.
By the first and third harmonic an index for the vessel elasticity was
calculated: vessel elasticity = Power in % of 3.harmonic/ Power in % der
1.harmonic.
Results: During cold stimulation we found a significant decrease
in the ophthalmic artery elasticity and a significant decrease in the
Endothelin-1 plasma concentration. In patients with Low Tension Glaucoma,
who showed no sign of arteriosclerosis we found an overhelming decrease
in ophthalmic artery elasticity and no decrease in the Endothelin-1 plasma
concentration. In total there was a significant correlation between the
decrease in the Endothelin-1 plasma concentration and change in ophthalmic
artery elasticity during cold stimulation.
Conclusion: Patients with Low Tension Glaucoma without signs of
arteriosclerosis revealed a significant different pattern of reaction
during cold stimulation in respect to Endothelin-1 and ophthalmic artery
elasticity.