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Impressum
The effect of high dosage magnesium on ocular blood flow and visual function in glaucoma patients
Mollenhauer K. A., Pillunat L. E., Bernd A. S., Müller M.F., 1Boehm A. G.
University Eye Hospital Dresden, Germany; 1Shiley-Eye Center, UCSD, San Diego, CA, USA
It has been shown that systemic high dosage application of magnesium
leads to relaxation nof vasospasm in small vessels. Especially in normal
pressure glaucoma (NPG) patients, were vasospasm might be one of the major
pathogenic factors, the effect of magnesium seems to be of major interest.
Aim: of this study was to examine th effect of oral magnesium OBF
and visual function in glaucoma patients.
Methods: In a retrospective, clinical study 57 NPG patients and
152 HPG patients receiving magnesium 40mg systemically three times daily
were evaluated. The evaluated parameters were blood pressure, heart rate,
intraocular pressure (IOP) and the mean defect of the visual field (Humphrey
30-2). OBF and ocular pulse amplitudes (PA) were measured by means of
the OBF-System (UK) Ltd. At baseline, 1-3 month, 4-6 m., 7-9 m.,10-12
m., 12-18 month after initial dosing. Data were analyzed by multiple regression
analysis.
Results: In the HPG group all parameters did not show any significant
change after 3 month of treatment. After 6 month OBF was significantly
increased from 782.72µl/min to 901.23µl/min and after 18 month
PA showed a significant increase from 1.99-2.3. In the NPG group, however,
there was found no significant change with regard to any of the hemodynamic
parameters measured. MD decreased significantly from -7.16 to -5.86 after
3 month and from -7.47 to -6.63 after 6 month of treatment.
Conclusion: Visual field defects showed a significant decrease
in the NPG group. This effect, however, is not due to an improvement of
ocular hemodynamics and suggests a direct neuroprotective capability of
magnesium. The improvement of ocular hemodynamics in the HPG group did
not lead to any improvement of visual function, This observation, however,
suggests that also in HPG an initial imbalance of ocular hemodynamics
might be of pathogenetic importance.