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Impressum
Chronological association between the use of Latanoprost and the development of a serous detachment of the neurosensory retina. A case-report
Mornhinweg S., Coracas A., Eckardt C.
Augenklinik der Städtischen Kliniken Frankfurt am Main-Höchst, Gotenstrasse 6-8, 65929 Frankfurt
Introduction: A relationship between the application of Latanoprost
and cystoid macular edema in pseudophakic eyes has already been described
in ophthalmological literature. We report on a case of serous detachment
of the neurosensory retina after the application of Latanoprost.
Case: A 59-year-old male patient consulted us because of a reduction
of near vision and metamorphopsia since one week. He could no longer read
with his left eye and had difficulties also with his right eye. Six weeks
earlier a high eye pressure was found and was treated since eight days
with Alphagan twice a day and Latanoprost once a day. The anamnesis revealed
no other eye diseases, but a high cholesterol level and a euthyreoid struma.
Findings: Visual acuity was 0.5 on the right and 0,2 on the left
eye. Eye pressure was 18mmHg on the right and 26mmHg on the left eye.
On both eyes a moderate cataract with vacuoles could be observed. The
posterior pole of the right eye showed a serous retinal detachment at
the area of the vascular temporal arcades, reaching the edge of the optic
disc. On the left eye the detachment affected the whole macular region.
Angiography pictures revealed a blockade of background fluorescence in
the early phase and a hyperfluorescence in the late phase at the edematous
area. 5-6 days after breaking off the treatment with Latanoprost the patient
could read normally again. The treatment with Alphagan was not interrupted.
Ocular examination two months later showed no evidence of edema, which
was comfirmed by fluorescein angiography.
Conclusion: In this case the chronological association between
the use of Latanoprost, the development of a serous retinal detachment
and the regression of the detachment following cessation of the drug suggests
a causal relationship between the use of Latanoprost and the serous detachment.
Such a secondary effect of this drug has not been described yet either
in this form or in absence of an altered blood-retinal barrier.