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Impressum
Temporal contrast sensitivity using Erlangen-full-field flicker test in patients after penetrating keratoplasty.
Nguyen N. X., Horn F. K., Seitz B., Cursiefen C., Langenbucher A., Küchle M.
Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany (Chairmann: Prof. Dr. Dr. h.c. GOH Naumann)
Background: Purpose of this study was to evaluate feasibility
of temporal contrast sensitivity testing using full-field flicker stimulation
in patients after penetrating keratoplasty (PK) and to assess whether
this method is influenced by postoperative corneal topographic changes.
Methods: Fourty-five patients (age 46.5±14.2 years) following
PK and 194 age-matched controls were included in this study. The postoperative
interval was 11.8 ± 10.2 months. Patients with pre-existing glaucoma
or any postoperative intraocular pressure elevation were excluded. The
indications for PK were 54% in keratoconus, 38% in Fuchs´ dystrophy
and 8% in stromal dystrophies. Temporal contrast sensitivity was determined
with sinusoidally flickering light (37.1 Hz) of constant mean photopic
luminance (10cd/m²) presented in a full-field bowl with an increasing
threshold strategy.
Results: Mean temporal contrast sensitivity was not different between
patients after PK (1.49±0.13, range 1.26-1.78, confidence interval
1.45- 1.53) and controls (1.55±0.17, range 1.16-1.98, confidence
interval 1.47- 1.51, p=0.98). No significant correlation between temporal
contrast sensitivity and visual acuity could be found in patients after
PK and in normals (p=0.3). In patients after PK temporal contrast sensitivity
was statistically independent of keratometric astigmatism (p=0.7), topographic
astigmatism (p=0.4), spherical equivalent (rp=0.7) and central corneal
thickness (p=0.7).
Conclusions: Temporal contrast sensivity using full-field flicker
stimulation seems to be feasible in patients after PK and does not depend
on topographic changes of the cornea. The results indicate that the full-field
flicker test may be helpful as a supplement to differentiate early glaucoma
from ocular hypertension in patients after PK. Supported by BMBF (IZKF
Erlangen, project B 13) and DFG (SFB 539)