Abstract 99. Jahrestagung der DOG, 29. 9. - 2. 10. 01 im ICC, Berlin

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Impressum



Presentation of a multicentric, prospective, randomized study for treatment of a central retinal artery occlusion with local intraarterial fibrinolysis.

1Schmidt D., 2Schumacher M., 3Mueller A., 3Kampik A.

1Univ.-Augenklinik, 2Sektion f. Neuroradiologie Freiburg, 3Univ.-Augenklinik München

Goal of examination: Judgement of local intraarterial fibrinolysis (LIF).
Methods: In this prospective study, patients with a central retinal artery occlusion (CRAO) should be either treated with LIF (max. 50 mg rt-PA or 1.5 Mio Urokinase, respectively) or conservatively (isovolemic hemodilution). In both groups, massage of the globe and treatment of the blood pressure should be carried out, immediately before the treatment (LIF or hemodilution) in an equal way. Then, the patients should be treated with aspirin ® or in special situations with Marcumar ®. In this study probably 14 clinics will participate. Kriteria for exclusion are reported on in detail. Kriteria for judgement are: visual acuity, visual field, stage of CRAO, and general disease.
Results: Up to now, several preliminary studies have been carried out: examinations with conservative treatment (Neubauer et al. 2000, on the minimal invasive treatment in a clinically complete CRAO) as well as the treatment with LIF in 3 clinics (Bern, Freiburg, Hamburg).
Conclusion: The statistical comparison of the results of the conservative treatment and of the LIF treatment is decisive for the treatment of an CRAO in the future.



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