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Impressum
Measurement of retinal nerve fiber layer thicknesss in glaucomatous and normal eyes by means of ellipsometer corrected for corneal aberration
1Schmidt E., 1Scheuerle A. F., 2Gölz S., 2Bille J., 1Burk R. O. W.
1Dpt of Ophthalmology, University of Heidelberg, INF400, 69120 Heidelberg 2Institute of applied physics, University of Heidelberg, 69121 Heidelberg
Objective: A recenty developed ellipsometer was used to measure
differences in retinal nerve fiber layer thicknesss (RNFLT) by quantification
of phase shift in healthy and glaucomatous subjects. The disturbing influence
of double refraction, mainly produced by an aspherical cornea, was minimized
by the Mueller formula.
Methods: We examined two groups: 1) a total of 14 healthy eyes
of 14 volunteers and 2) 12 glaucomatous eyes of 10 patients. Groups were
devided by characteristic visual field defects and intraocular pressure.
The RNFLT profile and the mean height were measured along a 360°-circle
( 0° temp., 90° sup., usw) with 1,45-fold diameter centered around
the optic disc. Nine parameters of the contour line including height and
position of a) maxima, b) minima und c) max. height variation of contour
line were measured and analyzed.
Results: Volunteers: mean height of RNFLT along the circle was
89±12µm, mean height of maxima was 160±20µm
at 84±20° (sup) and 170±20µm at 278±26°
(inf) respectively, mean height of minima was 40±10µm at
0±13° (nasal) and 25±5µm at 195±16°
(temp.) respectively. Max. height variation of contour line was 145±20µm.
Glaucoma: mean height of RNFLT was 72±12µm, mean height of
maxima was 125±30µm at 87±26° (sup) and 120±35µm
at 278±15° (inf) respectively, mean height of minima was 35±10µm
at 357±21° (nasal) and 30±5µm at 199±25°
(temp.) respectively. Max. height variation of contour line was 100±30µm.
Following parameters showed significant differences (p<0,05): a) mean
height of RNFLT, b) mean height of maxima (sup., inf.), and c) max. height
variation of contour line.
Discussion: Four parameter demonstrated significant differences
between the groups of volunteers and glaucomatous eyes. In order to use
the ellipsometer in clinical routine the handling and momentarily difficult
data evaluation must be automated and simplified.