Anmeldung zur Tagung
Registration
Grußwort
Invitation
Themen
Topics
Allgemeiner Ablauf
General overview
Wissenschaftliches Programm
Scientific program
Kurse
Courses
Symposien
Symposiums
Frühstück mit Spezialisten
Breakfast with specialists
Arzthelferinnen-Fortbildung
Rahmenprogramm
Social program
DOG Information
DOG Information
Allgemeine Informationen
General Information
Autorenindex
Index of Authors
Ausstellerliste
Exhibitors
Sponsoren
Sponsors
Teilnahmegebühren
Registration fees
Impressum
Intraocular Injection of Crystalline Cortisone as Treatment of Progressive Exudative Age-Related Macular Degeneration
Soefker A., Jonas J. B.
Department of Ophthalmology and Eye-Hospital, Faculty of Clinical Medicine Mannheim of the Ruprecht-Karls-University Heidelberg
Objective: To report on clinical outcome of patients receiving
an intravitreal injection of crystalline cortisone for treatment of progressive
exudative age-related macular degeneration.
Methods: The prospective consecutive non-comparative interventional
case-series study included 54 patients with progressive exudative agerelated
macular degeneration with subretinal neovascularization and progressive
loss of vision. The patients received a single intravitreal injection
of 25 mg triamcinolone acetonide in topical anesthesia. Mean follow-up
time was 2.85 ± 2.24 months (median, 2.3 months).
Results: Comparing the last postoperative examination with the
preoperative examination, an increase in visual acuity was found in 36
patients (36/54=66.7%), and a decrease in visual acuity was observed in
11 patients (11/54=20.3%). Seven patients (7/54=13.0%) did not show a
change in visual acuity. Area of subfoveal fluorescein leakage as measured
by fluorescein angiography decreased in 18 of 26 (69.2%) patients with
postoperative fluorescein angiograms available. In 8 patients (8/26 =
30.8%), the area of fluorescein leakage was postoperatively larger than
preoperatively. Intraocular pressure increased significantly (P=0.001)
from 15.4 ± 2.8 mm Hg (n=54) preoperatively to 25.5 ± 12.9
(n=29) at the fifth postoperative examination 77.6 ± 33.3 days
after the injection. Degree of nuclear cataract, cortical cataract, and
posterior subcapsular cataract increased significantly (P<0.05) during
the study period.
Conclusion: Intravitreal injection of crystalline cortisone may
be useful in the treatment of progressive exudative age-related macular
degeneration. Side-effects such as elevated intraocular pressure and progressive
cataract have to be taken into account.