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Impressum
Efficacy of dexamethasone-phosphate 0.1% eye gel in comparison to prednisolone-acetate 1% eye suspension in the treatment of postoperative inflammation after cataract surgery
Struck H. G., Bariszlovich A.
Martin-Luther-University Halle-Wittenberg, Department of Ophthalmology, Magdeburger Str. 8, 06097 Halle/Saale, Germany
Objective: Dexamethasone and prednisolone are halogenated glucocorticoids
with a potent antiinflammatory effect. Both agents are topically applied
routinely after intraocular surgery to prevent the breakdown of the blood-aqueous
barrier and inhibit cellular infiltration into target tissues.
Methods: A prospective, multi-centre, clinical parallel group study
was conducted to assess the efficacy of a new dexamethasone-phosphate
0.1% eye gel (group I, n = 117) in comparison to prednisolone-acetate
1% eye suspension (group II, n = 119) with a total of 236 patients, aged
39 - 92 years, following cataract surgery. Both drugs were given four
times a day for 14 days starting 24 ± 4 hours after surgery. Criteria
for evaluation were the reduction of anterior chamber flare and of inflammation
severity score. Laser photometry (LFM-500, KOWA) and slit lamp assessment
were performed between the last preoperative and 14th postoperative day.
Results: There were no statistically significant differences between
the treatment groups concerning efficacy criteria. The mean reduction
of anterior chamber flare from Day 1 to day 14 postoperatively was 8.34
± 20.80 photons/msec under dexamethasone 0.1% eye gel and 5.72
± 16.70 photons/ msec under prednisolone 1% eye suspension, respectively.
The mean reduction of inflammation severity score was 1.8 ± 1.3
points in group I and 2.0 ± 1.1 points in group II.
Conclusion: The results of the study underline the protective effect
of dexamethasone-phosphate 0.1% eye gel on the blood-aqueous barrier.
This drug is an effective steroidal anti-inflammatory agent for topical
use following cataract surgery and intraocular lens implantation.