Abstract 99. Jahrestagung der DOG, 29. 9. - 2. 10. 01 im ICC, Berlin

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Clinical differences of Varicella zoster and Herpes simplex virus induced Keratouveitis

Torun N., Scherer M., Pleyer U.

Department of Ophthalmology Charité, Campus Virchow-Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin

Objective: The aim of this study was to compare the clinical picture, morphological findings, progress and its consequences for the therapy in patients with intraocular inflammation of viral etiology.
Patients and methods: Thirty patients with viral induced keratouveitis were included within in the period 1/1999 to 4/2001. The specific etiology was established by evaluating the IgG antibody synthesis (Micro-ELISA) in the aqueous humor for varicella zoster virus (n=12; group I) and herpes simplex virus (n=18; group II). The results of the slit lamp examination, tonometry, ophthalmoscopy and the visual acquity were documented and analysed retrospectively for all patients. The average follow up was 6 months for group I and 4.4 months for group II. All patients received topical and systemic antiviral therapy.
Results: There was no difference concerning the severity of the disease, corneal affection and intraocular inflammation between both groups. Nine patients (75%) of group I and only 3 patients (17%) of group II had an elevated intraocular pressure. Seven patients of group I (58.3%) showed an improvement under therapy in contrast to five of group II (27.7%).
Conclusion: An elevation of intraocular pressure seems to occur more often in patients with VZV keratouveitis.




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