1Voigt U., 1Lasch A., 1Hammer M., 1Schweitzer D., 2Schiel R., 1Strobel J.

1Augenklinik, 2Klinik für Innere Medizin II, Friedrich-Schiller-Univ. Jena

Goal: Vasocostriction and increased oxygen saturation in retinal vessels are observed during a respiration of pure oxygen. The reaction of oxygen saturation in retinal vessels during oxygen provocation will studied in a comparism between diabetics (withouth and with mild retinopathy) and healthy probands.
Methods: Using the Jena Imaging Spectrometer, the oxygen saturation was measured in retinal arteriols and venols before, during (6 min. after start) and 15 minutes after stopp of oxygen respiration in 13 diabetics and 13 healthy probands. Additionally, blood pressure, concentration of blood glucose and HbA1c were registrated.
Results: In arteriols the oxygen saturation increased in both groups during oxygen respiration significantly (p<0,05). The saturation increased from 89±6% to 96±7% in the control group and from 87±7% to 91±10% in the diabetic group. After interruption of oxygen respiration, the oxygen saturation decreased to 88±8% in the control group and to 90,5±10% in diabetics. Only in normals this difference was significant (p<0,05). In venols, the oxygen saturation increased during oxygen respiration in both groups from 52±12% to 77±13% and decreased after stopp of provocation to 54±12%. The differences were significant (p<0,05). There were no singnificant differences of oxygen saturation detectable in arteriols and venols in comparison between healthy probands and diabetics.
Conclusions: Diabetics without and with mild non proliferative retinopathy have a normal oxygen consumption in retinal tissue during oxygen provocation. A disturbance of oxygen consumtion is expected in patients with advanced retinopathy.
Supported by OphthalmoInnovation Thüringen: TMWFK Grant No 821198

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