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Impressum
Influence of hyperhydration on retinal microcirculation - a retinal vessel analyser study
Wecke T., Kuchenbecker J., Vorwerk C. K., Vilser W., Behrens-Baumann W.
Otto-von-Guericke-University, Department of Ophthalmology, Magdeburg
Background: In this pilotstudy we investigated the influence of
hyperhydration (water drinking model) on retinal microcirculation, systemic
blood circulation, and intraocular pressure in normal healthy individuals.
Methods: Mean diameter of retinal arterial branch vessels of 6
healthy individuals were recorded for one minute by the Retinal Vessel
Analyzer (RVA). Simultaneously blood pressure, pulse and oxygen saturation
were recorded for baseline. Intraocular pressure was measured immediately
after RVA measurements. Afterwards all included individuals drank 1 liter
of water within 5 minutes. Recording of all baseline parameters were repeated
after 15, 30, and 60 minutes. Changes of all obtained parameters were
analyzed for statistically significance by variance analysis.
Results: The average vessel diameter revealed a slow decrease after
15 min (mean difference -4,2) and returned to almost baseline levels after
60 min. The average systolic blood pressure raised, reaching a maximum
after 15 min (mean difference -10,0mmHg). The pulse decreased over the
whole experiment (mean difference -5,5 after 60 min). Intraocular pressure
showed a moderate increase with a maximum after 30 min (mean difference
+2,3). All parameters did not showed a significant statistical difference.
Conclusions: In normal, healthy individuals hyperhydration has
no significant influence on retinal arterial vessels diameter, systemic
blood pressure parameters as well as intraocular pressure. In further
investigations we plan to evaluate, if this method is adequate to distinguish
between pathological retinal and systemic vessel reactions of primary
open angle glaucoma, ocular hypertension in comparison to healthy individuals.