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Impressum
Measurement of macular pigment density in patients with age-related macular degeneration
Wolf S., Jahn C., Nestler A., Barth T.
Klinik und Poliklinik für Augenheilkunde, Universität Leipzig, Liebigstraße 10-14, 04103 Leipzig
Purpose: There is a growing body of evidence to indicate that
oxidative damage plays a role in the pathogenesis of age-related macular
degeneration (AMD). Consequently, the possibility that the antioxidant
properties of macular pigment (MP) confer protection against AMD has been
postulated. A proved protective effect of MP may be of therapeutic value,
as it has recently been reported that human MP can be modified with dietary
supplementation. This study was conducted to measure the MP density in
patients with AMD.
Methods: The measurement MP density performed with a scanning laser
ophthalmoscope. First, fundus reflectance images at 488- and 514 nm argon
laser wavelengths were recorded. Thereafter, these images were corrected
for eye movements, the images converted to log reflectance maps and digitally
subtracted. The resulting images are functional images of MP density.
After correction for the difference in the MP absorption at 488 and 514
nm, for the lens density, and for differences in the intensity of the
laser light at different wavelengths MP density was evaluated in the fovea.
Results: Macular pigment density was quantified in 34 healthy subjects
and 33 patients with exudative AMD. MP density in the fovea was significantly
reduced in patients with exudative AMD (p<0,05). Relative MP density
was 0,32 ± 0,20 in healthy subjects and 0,22 ± 0,10 among
patients with AMD.
Conclusion: Measurement of MP density can be performed by analysing
reflectance images recorded with scanning laser ophthalmoscope. Our data
show a reduction of MP density in patients with exudative AMD. Further
studies are needed to test if the reduction of MP densities a primary
or secondary phenomenon in exudative AMD.