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Effects of Rimexolone on Endotoxin-induced Uveitis (EIU)

1Porstmann A. U., 1de Ruijter M., 2Sedláková K., 1Pleyer U.,
1Humboldt-Universität zu Berlin, Charité Campus Virchow-Klinikum, Augenklinik (Berlin)
2VFN, Charles Universität, Universitäts-Augenklinik (Prag)

Purpose: To evaluate the anti-inflammatory effect of rimexolone 1% in EIU. Rimexolone 1% ophthalmic suspension (Vexol 1%, Alcon) has been shown to have a lower IOP-elevating potential than prednisolone acetate.
Method: Uveitis was induced in Lewis rats (n=50) by LPS injections (Salmonella typhimurium) intraperioneally. Rats either (1) did not receive any treatment (LPS-control), received 20µl of topical (2) rimexolone 1%, or (3) prednisolone acetate 1% every second hour. 8 and 24 hours after endotoxin-injection and therapy, a clinical scoring of the inflammation was performed and aqueous humor was analyzed for protein and cell content.
Results: Already 8h after induction of EIU, treatment with rimexolone 1% showed a tendency to inhibit the cellular inflammatory reaction in the anterior chamber compared to untreated controls. 24h after EIU, the mean number of infiltrating inflammatory cells in the aqueous humor was 1612±283/µl, 68±21/µl, and 5±2/µl for animals without treatment, rimexolone 1%, and prednisolone 1% respectively (p<0.001). Changes in protein content were comparable, although not statistically significant.
Conclusions: Rimexolone and Prednisolone were comparably effective in modulating endotoxin-induced uveitis.

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