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TPA and Gas Injection in Patients with Sub-retinal Hemorrhages due to Age-related Macular Degeneration and Comparably Good Vision

1Schulze S., 2Hesse L.,
1Philipps-Universität Marburg, Medizinisches Zentrum für Augenheilkunde (Marburg)
2Augenklinik der SLK-Kliniken (Marburg)

Purpose: It's currently discussed if patients with subretinal hemorrhages (SRH) due to age-related macular degeneration (ARMD) who possess visual acuity of 0.1 or better have benefit from intravitreal injection of TPA and gas.
Method: We evaluated retrospectively the reports of 33 patients with SRH who came to our clinic with a visual acuity of 0.1 or better between April 1996 and September 2001. All patients (16 men, 17 women, mean age 76.8 years) underwent TPA and gas injection. Evaluated parameters of all patients were visual acuity (preoperatively, 1 week and 3 months after surgery), duration and dimension (diameter and thickness) of bleeding.
Results: The patients showed a mean visual decrease of one visual step 3 months after TPA and gas. We found a strong negative correlation between the preoperative VA and the postoperative VA after 1 week and 3 months (p<0.01) due to enlargement of underlying SRNV. Preoperative VA remains an independent predictor of visual outcome after multiple regression analysis. Thickness of SRH is negatively correlated with the postoperative VA after 1 week.
Conclusions: Independently of the good results in treatment of SRH due to ARMD with TPA and gas in patients with low preoperative vision there seems to be no benefit for patients with a comparably good VA of 0.1 or better.

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