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Amiodarone Induced Lipidosis: Morphological and Functional Examination in the Retina of Mice

1Bredehorn T., 1Harm P., 1Simon E., 1Holzhausen H.-J., 2Duncker G. I. W.,
1Martin-Luther-Universität, Klinik und Poliklinik für Augenheilkunde, Arbeitsbereich für experimentelle Elektroophthalmologie (Halle/Saale)
2Martin-Luther-Universität, Klinik und Poliklinik für Augenheilkunde (Halle/Saale)

Purpose: The purpose of this study was to evidence and localise lipidosis-like alterations caused by amiodarone, a cationic-amphiphilic drug, in the retina of mice by means of electroretinography compared with ultrastructural investigations.
Method: Pigmented mice of the stock Black CL 57 were fed with amiodarone (average 176 mg/kg body weight) for 22 weeks. The ERG measurements were done initially and after 22 weeks. Afterwards the retinae were prepared for the histology.
Results: After 22 weeks there were no significant changes in the following electroretinographic parameters: a-wave amplitude, b-wave amplitude, a-wave time to peak and b-wave time to peak. The histological preparations of the retinae showed lipidosis-related ultrastructural inclusions in the outer segment of the receptorcells.
Conclusions: Minimal lysosomal inclusions were documented in the outer segment of the receptorcells by ultrastructural methods, without any influence on the ERG-parameters. The standard-ERG used in this study seems not to be suitable to detect functional changes in the retina caused by amiodarone.

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