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Effect of Dorzolamide on Visual Function in Age-related Maculopathy

Weber A., Remky A., Lichtenberg K., Arend O.,
RWTH Aachen, Universitätsaugenklinik (Aachen)

Background: Several studies revealed a positive effect of carboanhydrase inhibitors (CAI) on ocular circulation. Local CAI may prevent functional losses in provocation tests e.g. hypercapnia. This study was designed to prove a potential protective influence of dorzolamide on retinal function in patients with age-related maculopathy (ARM).
Methods: In a randomized placebo controlled study we included 36 patients with ARM and good visual acuity (>0.4) and treated with dorzolamide or artificial tears (as placebo) for a period of 12 weeks 3x/day. Retinal function was quantified pre- and post treatment using static blue-on-yellow-perimetry (Humphrey Prg.10-2).
Results: The overall population showed a significant increase of mean threshold (p = 0.037). The kind of therapy had no influence on the change of mean thresholds (verum; increase of 1.4 dB; placebo increase of 1.2 dB; ANOVA-interaction: p = 0.87).
Conclusions: This study showed no significant effect of local dorzolamide on short-wavelength sensitive (SWS) cone mediated sensitivity in ARM. Future studies with longer treatment periods seem to be meaningful to prove beneficial effects of dorzolamide in ARM.

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