Programm & Abstracts                 "Innovationen in der Augenheilkunde"

Aktuelle Tagungsinformationen
   News and Updates

Anmeldung zur Tagung
   Registration
Hotelbuchung
   Hotel Registration
Grußwort
   Welcome address
Beteiligte Gesellschaften
   Societies involved
Eröffnung des Kongresses
   Opening Ceremony
Preise
   Awards
Wissenschaftliches Programm
   Scientific program
Posterpräsentationen
   Poster Presentation
Kurse
   Courses
Begleitende Veranstaltungen
   Collateral Events
Rahmenprogramm
   Social program
Jubiläumsparty
   Jubilee Party
DOG Information
   DOG Information
Allgemeine Informationen
   General Information
Autorenindex
   Index of Authors
Ausstellerliste
   Exhibitors
Sponsoren
   Sponsors
Teilnahmegebühren
   Registration fees
Impressum



DOG Homepage

Identification of Leptin in Aqueous-humor in Diabetic and Non-diabetic Patients

1Bergua A., 2Schoof E., 2Dötsch J., 2Gröschl M., 1Schönherr U., 2Rascher W., 1Küchle M.,
1Friedrich-Alexander-Universität, Augenklinik (Erlangen)
2Friedrich-Alexander-Universität, Kinderklinik (Erlangen)

Purpose: To determine the presence of leptin in human aqueous humor and to analyze the influence of diabetes mellitus.
Methods: Leptin concentrations in aqueous humor and serum from cataract operated diabetic (n=11) and non-diabetic patients (n=8) were determined using a specific radioimmunoassay.
Results: In the control group, leptin concentration in aqueous humor was 22.6 ± 4.5 pg/ml and in serum 4.1 ± 1.7 ng/ml. In diabetic patients, leptin concentrations in aqueous humor were 32.6 ± 8.7 pg/ml (serum: 3.67 ± 2.0 ng/ml). There was a linear correlation between leptin serum and aqueous humor concentrations in normals (r=0.75, p=0.003). This relationship was not present in non-diabetic patients. Although higher leptin concentrations in aqueous were observed in patients with diabetes mellitus, the difference in comparison to controls was not statistically significant.
Conclusions: Leptin can be found in aqueous humor in all subjects investigated. Our results indicate a disordered balance of leptin concentrations in serum and aqueous humor in patients with diabetes mellitus. This may be related to a compromised leptin transport into aqueous humor in diabetic patients.

Zurück/Back