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The Influence of the Screen Luminance to the Response of the Multi-focal Electroretinogram

1Schimitzek T., 2Bach M.,
1Albert-Ludwigs-Universität, Augenklinik (Freiburg)
2Albert-Ludwigs-Universität Freiburg, Augenklinik, Elektrophysiologisches Labor (Freiburg)

Purpose: The multifocal electroretinogram (mfERG) is one of the latest advancements in electrophysiologic diagnostic. Aim of the study is to evaluate the influence of the screen luminance to the evoked potentials.
Method: We examined 5 male and 5 female volunteers in the age of 22 to 52 years (median 28 y) with the mfERG (61 Hexagon) in mydriasis. In each examination the luminance of the bright areas of the screen was set to 150, 300 und 500 cd/m2. We recorded the potentials from DTL-electrodes using the Verisä Science 4.4 program. Analysis was based on the 5 ring averages.
Results: The influence of the luminance was most distinct in the centre. With decreasing luminance the latency of N1 increased from 15.8 ms to 17.5 ms. In all the peripheral rings the latency was unchanged. The largest amplitude (-55.3 nV/deg2) was in the centre at 500 cd/m2 and reached only 84.1 and 86.6% of this value at the lower luminance settings. In all peripheral rings the amplitude decreased over 91.0 to 81.5% by diminishing the luminance. The latency of P1 remained the same at all luminance levels (30 ms). In the centre the amplitude depended little on luminance (102.1 und 93.8%), but strong in the periphery (86.4 and 75.1%).
Conclusions: The Influence of the luminance in the mfERG-responses was generally low in the range evaluated. N1 showed the strongest dependency on luminance. The latency of P1 was not influenced at all, it's amplitude decreased by diminishing the stimulus luminance. Our results support the advice of the ISCEV to conduct a mfERG examination at a luminance of 100-200 cd/m2.