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The Influence of Brimonidine and Dapiprazole on Pupil Size at Different Illumination Levels

1Marx-Groß S., 1Dick H. B., 2Krummenauer F., 1Pfeiffer N.,
1Johannes-Gutenberg-Universität Mainz, Universitäts-Augenklinik (Mainz)
2Johannes-Gutenberg-Universität Mainz, Koordinierungszentrum für Klinische Studien (KKS) (Mainz)

How is the influence of brimonidine and dapiprazole on pupil dilation at scotopic (0.03 lux) and low mesopic (0.82 lux) conditions? Is there an influence at high mesopic level (6.4 lux)?
Patients and Methods: 19 healthy volunteers received two different eye drops: brimonidine (Alphagan) und dapiprazole (Remydrial). Before and after application we measured the pupil diameter with the Procyon Pupillometer at 3 different illumination levels.
Results: At scotopic level we determined a reduction of pupil dilation of about 2.4 mm 40 minutes after application of both ophthalmic solutions. At low mesopic illumination the influence was 1mm and at high mesopic illumination about 0.5 mm.
Conclusion: Both ophthalmic solutions lead to a reduced dilation at a scotopic level.It is possible to dispense them to patients with photic phenomena by night. At high mesopic illumination there is only a slight influence on the pupil size, which is not relevant for every-day life.

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