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Experimental Observations on Intraocular Toxicity of Intravitreal Crystalline Triamcinolone

Spandau U.,
Ruprecht-Karls-Universität Heidelberg, Fakultät für klinische Medizin Mannheim, Augenklinik (Mannheim)

Purpose: Clinical studies have demonstrated a positive clinical effect of intravitreal crystalline triamcinolone acetonide on proliferative and edematous retinal diseases such as diabetic retinopathy. Purpose of this study was to investigate the possible toxic effect of crystalline triamcinolone acetonide on neovascularization in a retinopathy of prematurity (ROP) mouse model.
Methods: Mice were incubated from P7-P12 with 75% O2. On P12, 1 microl of crystalline triamcinolone acetonide was injected once into the vitreous. As control, 1 microl saline was injected into the contralateral eye. On P17, mice were sacrificed and eyes were histomorphometrically examined. Toxicity was assessed by counting the cells of the ganglion cell layer, the outer and the inner nuclear layers of the retina.
Results: The study group and control group showed no statistical significant differences (p>0.05) in the number of retinal ganglion cells (23 ± 2.1 cells per square grid versus 23 ± 2.3 cells per square grid), inner nuclear layer cells (92 ± 9.5 versus 89 ± 5.6) and outer nuclear layer cells (350 ± 53 versus 354 ± 30 cells per square grid).
Conclusions: The results of the present study suggest that intravitreal crystalline triamcinolone acetonide may not be associated with a decreased retinal cell count in young mice.

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