Programm & Abstracts                 "Innovationen in der Augenheilkunde"

Aktuelle Tagungsinformationen
   News and Updates

Anmeldung zur Tagung
   Registration
Hotelbuchung
   Hotel Registration
Grußwort
   Welcome address
Beteiligte Gesellschaften
   Societies involved
Eröffnung des Kongresses
   Opening Ceremony
Preise
   Awards
Wissenschaftliches Programm
   Scientific program
Posterpräsentationen
   Poster Presentation
Kurse
   Courses
Begleitende Veranstaltungen
   Collateral Events
Rahmenprogramm
   Social program
Jubiläumsparty
   Jubilee Party
DOG Information
   DOG Information
Allgemeine Informationen
   General Information
Autorenindex
   Index of Authors
Ausstellerliste
   Exhibitors
Sponsoren
   Sponsors
Teilnahmegebühren
   Registration fees
Impressum



DOG Homepage

Effects of Nimodipine on Ocular Circulation in Low-tension Glaucoma at Rest and During Increase of Blood-pressure by External Counterpulsation

1Michalk F., 2Michelson G., 3Harazny J., 4Werner U., 1Daniel W. G., 1Werner D.,
1Friedrich-Alexander-Universität, II. Medizinische Klinik (Erlangen)
2Friedrich-Alexander-Universität, Augenklinik (Erlangen)
3Friedrich-Alexander-Universität, Augenklinik, Labor für okuläre Perfusion (Erlangen)
4Friedrich-Alexander-Universität, Institut für klinische und experimentelle Pharmakologie und Toxikologie (Erlangen)

Purpose: Nimodipine is known to improve visual fields and clinical course of low tension glaucoma (LTG). In this study, we measured the changes in ocular circulation after nimodipine administration to investigate the hemodynamic causes for the known clinical benefit of nimodipine.
Methods: The following parameters were measured in 16 patients with LTG and 10 healthy age-matched controls before and 45 minutes after a single oral dose of 30 mg nimodipine: 1. Retinal capillary blood flow by Scanning-Laser-Doppler-Flowmetry in both eyes. 2. Mean blood flow velocity in ophthalmic artery by Doppler sonography in one randomly selected eye of each participant at rest and during increase of blood pressure by external counterpulsation (ECP).
Results: 1. Before administration of nimodipine, retinal blood flow was sig-nificantly reduced in LTG-patients compared with controls (262 ± 80 versus 487 ± 164 AU, p < 0.001). Nimodipine increased retinal blood flow in LTG-patients by 91 ± 73 % (p < 0.001) to values of healthy controls. In controls, retinal blood flow showed no changes by nimodipine. 2. Neither before nor after administration of nimodipine differences could be found in flow velocity of ophthalmic artery between LTG-patients and controls. Nevertheless, nimodipine increased in flow velocity of ophthalmic artery in LTG-patients by 7.3 ± 12.6 % (p < 0.05) and did not change flow velocity of ophthalmic artery in controls. ECP did not change flow velocity of ophthalmic artery at baseline or after nimodipine uptake.
Conclusions: Nimodipine normalizes impaired retinal circulation in LTG patients up to values of healthy controls, explaining the clinical effects. In controls nimodipine did not show any effects on retinal blood flow. In both groups maintenance of flow velocity of ophthalmic artery is not effected by nimodipine or by increase of blood pressure by ECP.

Zurück/Back