Programm & Abstracts                 "Innovationen in der Augenheilkunde"

Aktuelle Tagungsinformationen
   News and Updates

Anmeldung zur Tagung
   Registration
Hotelbuchung
   Hotel Registration
Grußwort
   Welcome address
Beteiligte Gesellschaften
   Societies involved
Eröffnung des Kongresses
   Opening Ceremony
Preise
   Awards
Wissenschaftliches Programm
   Scientific program
Posterpräsentationen
   Poster Presentation
Kurse
   Courses
Begleitende Veranstaltungen
   Collateral Events
Rahmenprogramm
   Social program
Jubiläumsparty
   Jubilee Party
DOG Information
   DOG Information
Allgemeine Informationen
   General Information
Autorenindex
   Index of Authors
Ausstellerliste
   Exhibitors
Sponsoren
   Sponsors
Teilnahmegebühren
   Registration fees
Impressum



DOG Homepage

End-points and Examination Parameters in Glaucoma Studies

1Yun S. H., 1Schwenn O., 2Troost R., 1Pfeiffer N.,
1Johannes-Gutenberg-Universität Mainz, Universitäts-Augenklinik (Mainz)
2Johannes-Gutenberg-Universität Mainz, Koordinierungszentrum für Klinische Studien (KKS) (Mainz)

Background: Glaucoma is defined as progressive optic neuropathy involving characteristic changes to optic nerve and visual field. It should be evaluated which parameters of examination and success are applied in glaucoma studies.
Method: Total 101 studies on clinical glaucoma therapy from the years 1996 to 1999 in frequently read journals are evaluated.
Results: Intraocular pressure was examined in all studies. The visual field respectively the morphology of optic nerve disc was only examined in 60% respectively 30% of the studies. The assessment of these parameters was often not defined, nonuniform and not easily comparable. In those cases success was explicitly defined, it was mostly defined with the intraocular pressure. The visual field and the morphology of optic nerve disc were endpoints in few studies. New diagnostic methods like laser scanning tomography, laser scanning polarimetry or short-wavelength automated perimetry were not yet in use.
Conclusions: So far, the intraocular pressure plays important role in the concepts of glaucoma studies, although it is not a part of the actual disease defintion. The slow progression makes it difficult to assess the success of a study by changes to visual field and optic nerve disc. New concepts like neuroprotection, improvement of blood supply or gene therapy require other parameters for success assessment.

Zurück/Back