Programm & Abstracts                 "Innovationen in der Augenheilkunde"

Aktuelle Tagungsinformationen
   News and Updates

Anmeldung zur Tagung
   Registration
Hotelbuchung
   Hotel Registration
Grußwort
   Welcome address
Beteiligte Gesellschaften
   Societies involved
Eröffnung des Kongresses
   Opening Ceremony
Preise
   Awards
Wissenschaftliches Programm
   Scientific program
Posterpräsentationen
   Poster Presentation
Kurse
   Courses
Begleitende Veranstaltungen
   Collateral Events
Rahmenprogramm
   Social program
Jubiläumsparty
   Jubilee Party
DOG Information
   DOG Information
Allgemeine Informationen
   General Information
Autorenindex
   Index of Authors
Ausstellerliste
   Exhibitors
Sponsoren
   Sponsors
Teilnahmegebühren
   Registration fees
Impressum



DOG Homepage

Mitomycin C for Local Treatment of Corneal Intraepithelial Neoplasia (CIN)

Ottenberg D., Richter M., Bechrakis N. E., Foerster M. H.,
Freie Universität Berlin, Klinikum Benjamin Franklin, Augenklinik (Berlin)

Background: Corneal intraepithelial neoplasia (CIN) is a rare, slowly progressing dysplasia of the corneal epithelium with low potential of malignancy. Until now treatment options included excision, radiation and cryotherapy.
Methods: We present an 81-year old patient with CIN treated by local application of mitomycin C 0,02% and with a one year follow-up and photo documentation.
Results: The patient had noticed visual deterioration in the left eye. Visual acuity was 0,2 on first examination. The histological examination of a corneal scrape performed in a different hospital, was consistent with the diagnosis of carcinoma in situ. Two cycles of mitomycin C eye drops four times daily for a time period of 14 days were given. During the treatment the CIN decreased rapidly until complete disappearance. Visual acuity increased to 0,4. During the treatment a reversible punctate keratitis developed. The 12 month follow up did not show any sign of CIN recurrence.
Discussion: In our case local application with mitomycin C was an effective and not aggressive treatment of CIN compared to other therapies such as excision, radiation and cryotherapy. The efficacy of local cytostatic substances (mitomycin C, 5-fluorouracil) is already described in small patient series in the literature.

Zurück/Back