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Partially Fluorinated Alcanes as Wash-out Solution after Silicone-oil Removal
Klär-Dißars U., Hoerauf H.,
Medizinische Universität zu Lübeck, Klinik für Augenheilkunde (Lübeck)
Introduction: Due to their high solubility for silicone oil, the partially fluorinated alcanes perfluorohexyloctane (F6H8) and perfluorobutylbutane (O44) can be used as a wash out solution for a more complete silicone oil removal.
Patients and Methods: A) 11 eyes were irrigated with F6H8 twice immediately after passive silicone oil removal. The silicone oil concentration in both F6H8 samples was measured quantitatively using optical emission spectroscopy (OES). B) 11 eyes were irrigated with O44 twice immediately after passive silicone oil removal. The silicone oil concentration in both O44 samples was measured quantitatively using OES (n=7) and / or infrared spectroscopy (n=7).
Results: A) The concentration in the first F6H8 sample was 75 ppm, and in the second sample 175 ppm. B) The mean concentration in the first O44 sample was 2137 ppm, and in the second sample 1681 ppm.
Conclusions: F6H8 and O44 are able to dissolve silicone oil remnants after silicone oil removal, however O44 seems to be more effective. Since the small amount of dissolved silicone oil is not causing problems, a clinical use would be restricted to patients with severe emulsification and glaucoma.