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Results of Macular-hole Surgery with ICG-assisted Peeling of the Internal Limiting Membrane

1Wolf S., 2Schnurrbusch U. E. K., 3Reichel M. B., 2Wiedemann P.,
1Klinik und Poliklinik für Augenheilkunde, Universität Leipzig (Leipzig)
2Universität Leipzig, Klinik und Poliklinik für Augenheilkunde (Leipzig)
3Klinikum Konstanz, Augenabteilung (Leipzig)

Purpose: Indocyanine green (ICG) staining of the internal limiting membrane has facilitated ILM peeling in macular hole surgery. However, it has been reported that ICG assisted peeling of the ILM may result in retinal damage and unfavorable functional outcome. Therefore, we have analyzed our visual and anatomical results of ICG assisted macular hole surgery.
Methods: This study consists of a retrospective series of eyes with macular holes stage II-IV according to Gass operated between 5/2000 and 6/2001 with ICG assisted ILM peeling. All patients underwent a standard three-port vitrectomy with surgical induced posterior vitreous detachment, staining of the ILM with ICG, peeling of the ILM in a circular manner around the fovea, and SF6 20% endotamonade.
Results: A total of 35 eyes was included into the study. Patients (27 female, 8 male) ranged in age from 52 to 80 years (mean: 63 ± 7 years). Mean follow-up was 12 ± 3 months. Anatomical closure of the macular hole was achieved in 33 (94%) eyes by one operation. Best corrected visual acuity ranged from 0.03 to 0.5 preoperatively. At last follow-up visual acuity ranged from 0.1 to 1.0. Visual acuity improved (> 2 lines) in 25 (71%) eyes and in 10 (29%) eyes visual acuity was stable (± 2 lines. In 10 eyes retinal pigment epithelium changes were noted. Visual field defects were not observed postoperatively.
Conclusion: The results of this retrospective analysis suggest that ICG assisted peeling of the ILM is a safe procedure without negative impact on the functional outcome. However, a randomized prospective study is needed to determine whether ICG assisted ILM peeling improves the clinical outcome in macular hole surgery.

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