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Posterior Capsule Opacification of the PMMA-IOL 751A® 2-5 Years Post-operatively

1Kojetinsky C., 2Porstmann A. U., 3Anders N., 2Nimsgern C., 2Müller V., 2Hartmann C., 2Tetz M.,
1Ludwig-Maximilians-Universität München, Augenklinik (München)
2Humboldt-Universität zu Berlin, Charité Campus Virchow-Klinikum, Augenklinik (Berlin)
3Augenklinik am Gendarmenmarkt (Berlin)

Purpose: Development of Posterior capsule opacification (PCO) is strongly influenced by material and design of the implanted intraocular lens (IOL). Some studies suggested a remarkebly strong PCO by PMMA-IOLs. A clinical study was performed to estimate the rate of PCO of the PMMA-IOL 751A® (Pharmacia).
Method: 36 eyes of 26 patients (mean age at examination time: 73,5 [60-87]) years were examined 2-5 years after implantation of the PMMA-IOL 751A®. All patients had standardized cataract surgery (Phacoemulsification) by the same surgeon. Postoperative therapy followed the standard protocoll. Patients with any ocular pathology resp. systemic disease influencing PCO development or systemic medication were excluded. Visual acuity and the rate of YAG-capsulotomies was determined; PCO was quantified by the EPCO®-picture analysis programme.
Results: 3 years postoperatively the rate of YAG-capsulotomies was 0%, after 4 years 23,1%. The EPCO®-score was in median 1,093 (0,347-3,0) and the median of visual acuity 0,80 (0,4-1,0) after 4 years.
Conclusions: The rate of YAG-capsulotomies ot the PMMA-IOL 751A® obtained in our study of 0% after 3 years is much lower than the rates reported from other investigations for PMMA-IOLs (ca. 22-38%) aswell as for acrylic IOLs (ca. 6-7%). In conclusion, we can not confirm previous studies which showed an increase of PCO by PMMA-IOLs. To compare and evaluate the EPCO-scores further investigations are needed.